منابع مشابه
Integrin signalling at a glance.
It has been brought to our attention that there is an error in the poster published in association with this article. Non-phosphorylated ICAP1 is shown to bind to the cytoplasmic tails of integrin β-subunits, whereas Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of ICAP1 is depicted as driving dissociation of ICAP1 from integrin β-tails. Although ICAP1 is indeed ...
متن کاملIntegrin ligands at a glance.
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently linked, heterodimeric molecules containing an and a subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 s...
متن کاملIntegrin trafficking at a glance.
Integrins are heterodimeric transmembrane receptors for extracellular matrix (ECM) components and they link the intracellular actin cytoskeleton to the cellular environment (Humphries et al., 2006; Hynes, 2002). The aand b-subunits of integrin heterodimers are type I membrane proteins that typically have a large extracellular domain and a short intracellular tail. Through different combinations...
متن کاملRho signalling at a glance.
Cells receive extracellular stimuli in the form of soluble molecules (growth factors, cytokines and hormones) that bind to cell surface receptors, adhesive interactions (extracellular matrix and cell-cell adhesion) or mechanical stresses (tension, compression and fluid shear stress). These stimuli act upon guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins (GAPs) to contr...
متن کاملThe integrin adhesome network at a glance
The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2009
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.018093